Final Conference Program

Download program: EPBRS-Congress2005_Prog.pdf

Thursday, 1st September

13.00–15.00 Academic Ceremony of the Medical Faculty, Johann Wolfgang Goethe University Frankfurt with
14.00-14.25 Bestowal of an Honorary Doctoral Degree (Dr. med. h.c.) upon David Charles Klein, Bethesda, USA
14.25-14.50 Bestowal of the Ernst and Berta Scharrer Medal upon Josephine Arendt, Guildford, United Kingdom
15.00-15.30 Coffee Break
15.30–17.45

Scharrer-Symposium
Chairs: A. Oksche, Gießen, Germany; K. Wake, Tokyo, Japan

15.30-15.40 H.-W. Korf, Frankfurt/Main, Germany
Opening Remarks
15.40-16.15 J. Arendt, Guildford, United Kingdom
Melatonin in humans
16.15-16.45 P. Pévet, Strasbourg, France Melatonin and the circadian clock in mammals
16.45-17.15 J. Fahrenkrug, Copenhagen, Denmark
PACAP – a multifacetted neuropeptide
17.15-17.45 Helmut Haas, Düsseldorf, Germany
Hypocretins: The timing of sleep and waking
17.45-18.15 Break
18.15

Special Lecture
D.C. Klein, Bethesda, USA
Evolution of the melatonin rhythm generating system
19.30 Get Together Party, X. Congress EPBRS

 

Friday, 2nd September

08.30-09.00

Welcome Addresses

E. Haindl
Stadträtin, Magistrat der Stadt Frankfurt am Main

J. Bereiter-Hahn
Vizepräsident der J. W. Goethe-Universität

J. Pfeilschifter
Dekan der Medizinischen Fakultät

H.-W. Korf
Präsident der EPBRS
09.00-11.15 Session I: The fly within – molecular clock mechanisms
Chair and Introduction: M. Hastings, Cambridge, United Kingdom
09.05-09.25 M. Merrow, Munich, Germany; Groningen, The Netherlands
The clock in the genes: clock properties and mechanisms in cells
09.25-09.45 C. Kyriacou, Leicester, United Kingdom
Disruption of cryptochrome rescues circadian rhythmicity in Period-null Drosophila mutants
09.45-10.05 H. Okamura, Kobe, Japan
Clock genes in mammalian cell clocks
10.05-10.25 G. T. J. Van der Horst, Rotterdam, The Netherlands
Structure - function analysis of mammalian CRY1
10.25-10.45 Y. Fukada, Tokyo, Japan
Roles of serine phosphorylation in regulation of mouse cryptochromes
10.45-11.15 Round Table Discussion
11.15-11.45 Coffee break
  Oral Presentations (10 min + 5 min discussion)
Chair: U. Albrecht, Fribourg, Switzerland
11.45-12.00 A. C. R. Diernfellner, T. Schafmeier, M.W. Merrow, M. Brunner, Heidelberg, Germany; Groningen, The Netherlands Molecular mechanism of temperature-sensing by the circadian clock of Neurospora crassa
12.00-12.15 D. Becquet, F. Guillaumond, M. P. Blanchard, M. Moreno, O. Bosler, A. M. François-Bellan, Marseille, France Temporal and spatial expression patterns of phosphorylated forms of ERK2 in the rat suprachiasmatic nucleus
12.15-12.30 T. M. Brown, A. T. Hughes, H. D. Piggins, Manchester, United Kingdom Gastrin-releasing peptide restores rhythms to the suprachiasmatic circadian clock of mice lacking the VPAC2 receptor
12.30-12.45 M. H. Hastings, J. A. O’Brien, A. J. Harmar, D. G. McMahon, E. S. Maywood, Cambridge and Edinburgh, United Kingdom; Tennessee, USA Fluorescence imaging of the suprachiasmatic circadian clockwork: dependence on peptidergic inter-neuronal signalling
12.45-13.00 D. J. Kennaway, J. A. Owens, A. Voultsios, T. J. Varcoe, Adelaide, Australia
Preservation of functional central rhythmicity and light entrainment, but not peripheral rhythmicity in clock mutants
13.00-14.00 Lunch break
14.00-15.15 Session II: Sensing light – with and without retina
Chair and Introduction: M. Rollag, Bethesda, USA
14.05-14.25 R. G. Foster, London, United Kingdom
A novel ocular photoreceptor: emerging roles and photosensory mechanisms
14.25-14.45 D. Whitmore, London, United Kingdom Light, entrainment and the role of cryptochrome in single, light responsive zebrafish cells
14.45-15.15

Round Table Discussion

Oral Presentations (10 min + 5 min discussion)

15.15-15.30 E. X. Anastasia-Greer, J. O. Liang, Cleveland, USA
Blinded by the light: exorhodopsin is regulated by OTX5 and PER3
15.30-15.45 S. S. Chaurasia, N. Pozdeyev, R. Haque, A. Visser, M. Iuvone, Atlanta, USA
Circadian clockwork machinery in neutral retina: evidence for the presence of functional clock components in cultured chick retinal cells
15.45-16.00 O. Dkhissi-Benyahya, W. De Vanssay, F. Flamant, H. M. Cooper, Bron and Lyon, France
Do MW-cones and rods contribute to circadian photoreception?
16.00-16.20 Coffee break
16.20-17.25 Session III: Shake-hands with the clock – hands of the clock
Chair and Introduction: E. Maywood, Cambridge, United Kingdom
16.25-16.45 J. Hannibal, Copenhagen, Denmark
Regulation of melanopsin expression by light and darkness
16.45-17.05 A. Kalsbeek, Amsterdam, The Netherlands
The network of (autonomic) clock outputs
17.05-17.25 Round Table Discussion

Oral Presentations (10 min + 5 min discussion)
17.25-17.40 T. Reischig, Göttingen, Germany
Input and output pathways of insect circadian clock neurons
17.40-17.55 L. P. Morin, J. H. Blanchard, New York, USA
Substance P in the hamster retinohypothalamic tract
17.55-18.10 C. Klisch, S. Mahr, H. Meissl, Frankfurt/Main, Germany
Circadian activity rhythms and phase-shifting of cultured neurons of the suprachiasmatic nucleus of the rat
18.10-18.25 M. R. Gorman, J. A. Evans, J. A. Elliott, San Diego, USA
Potent circadian effects of dim illumination at night in hamsters
18.25-18.40 A. Karakas, B. Gündüz, Bolu, Turkey
Suprachiasmatic nuclei directly regulate the rhythm of leptin hormone release in syrian hamsters (Mesocricetus auratus)
19.30 Reception by the Lord Mayor of Frankfurt in the Frankfurter Römer

 

Saturday, 3rd September

09.00-10.05 Session IV: Oscillators everywhere or clocks on the string?
Chair and Introduction: D. Kennaway, Adelaide, Australia
09.05-09.25 U. Schibler, Zürich, Switzerland
Cell-autonomous and systemic mechanisms in controlling mammalian circadian gene expression
09.25-09.45 G. Tosini, Atlanta, USA
A hierarchical network of clock regulates circadian rhythms in the mammalian retina
09.45-10.05

Round Table Discussion

Oral Presentations (10 min + 5 min discussion)
10.05-10.20 G. Helfer, R. Brandstätter, Birmingham, United Kingdom
Clocks here, clocks there, clocks everywhere? The molecular clockwork sparrow
10.20-10.35 S. Yasuo, M. Watanabe, M. Iigo, T. Yamamura, N. Nakao, T. Takagi, S. Ebihara, T. Yoshimura, Nagoya, Japan
Fine tuning of photoperiodic time information in avian brain
10.35-10.50 J. Olcese, H. Sikes, D. Resuehr, Tallahassee, USA
Induction of mPer1 mRNA expression in immortalized gonadotropes by gonadotropin-releasing hormone (GnRH): involvement of protein kinase C and MAP kinase signalling
10.50-11.20 Coffee Break
11.20-12.45

Session V/1: The pineal gland
Chair and Introduction: P. Ekström, Lund, Sweden
11.25-11.45 G. Cahill, Houston, USA
Clock mechanisms in Zebrafish
11.45-12.05 Y. Gothilf, Tel Aviv, Israel
Zebrafish Period2 expression pattern and its role in the development of the circadian clock
12.05-12.25 V. Csernus, Pecs, Hungary
The avian pineal gland
12.25-12.45 Round Table Discussion
12.45-13.45 Lunch
13.45-15.50 Session V/2: The pineal gland
Chair and Introduction: L. Vollrath, Mainz, Germany
13.50-14.10 V. Simonneaux, Strasbourg, France
A new way of regulating rodent Aanat gene expression, example of the Syrian hamster
14.10-14.30 A. Ho, Edmonton, Canada
Opposite effects of proteasome inhibitors on the adrenergic induction of arylalkylamine N-acetyltransferase in rat pinealocytes
14.30-14.50 M. Møller, Copenhagen, Denmark
The perivascular phagocytes of the pineal gland: an antigen presenting cell
14.50-15.05 Round Table Discussion
  Oral Presentations (10 min + 5 min discussion)
15.05-15.20 J. B. Zawilska, A. Lorenc, M. Berenzinska, B. Vivien-Roels, P. Pévet, D. J. Skene, Lodz, Poland; Strasbourg, France; Guildford, United Kingdom
Daily oscillation in melatonin synthesis in the turkey pineal gland and retina: diurnal and circadian rhythms
15.20-15.35 M. Iuvone, N. Pozdeyev, C. Taylor, R. Haque, S. S. Chaurasia, Y. Du, H. Fu, Atlanta, USA
Photic regulation of an arylalkylamine N-acetyltransferase/14-3-3 complex in the chicken retina
15.35-15.50 K. Ackermann, R. Bux, U. Rüb, C. Schomerus, H.-W. Korf, G. Kauert, J. H. Stehle, Frankfurt/Main, Germany
Characterization of diurnal patterns in Aanat mRNA, AANAT activity and melatonin content in autoptic human pineal tissue
15.50-16.20 Coffee break
16.20-18.10 Symposium “The Biological Clock in the Elderly”
Chair and Introduction: K. Kristensson, Stockholm, Sweden
16.25-16.45

C. Cajochen, Basel, Switzerland
Age-related changes in the circadian and homeostatic regulation of human sleep
16.45-17.05 F. Aujard, Brunoy, France
Age-related effects on the biological clock and its behavioural outputs in a primate
17.05-17.25 M. Bentivoglio, Verona, Italy
The aging SCN and cytokines: molecular, cellular and functional changes in rodents
17.25-17.40 M. Palomba, M. Nygård, M. Bentivoglio, K. Kristensson, Verona, Italy; Stockholm, Sweden
Changes of the GABA-ergic network in the suprachiasmatic nucleus of aged mice
17.40-17.55 B. Claustrat, S. Frezet, L. Gouthière, J. Brun, F. Claustrat, Lyon and Esvres sur Indre, France
Alterations of daily 6-sulfatoxymelatonin, plasma corticosterone and hepatic clock gene expression in the foliate deficient CBA mouse
17.55-18.10 C. Gronfier, H. Cooper, Bron, France
Photic sensitization in aged humans
18.15-19.00

Perspective lecture I:
S. M. Reppert, Worcester, USA
Transcriptional control of mammalian clockwork

Chair: P. Morgan, Aberdeen, United Kingdom
19.00-?? Posters, Wine, and Cheese

 

Sunday, 4th September

09.00-10.15 Session VI: The benefits of having melatonin receptors
Chair and Introduction: D. Sugden, London, United Kingdom
09.05-09.25 P. Delagrange, Suresnes, France
Therapeutic potential of melatonin ligands
09.25-09.45 M. Dubocovich, Chicago, USA
Are both MT1 and MT2 receptors involved in melatonin-mediated phase shifts of circadian rhythms?
09.45-09.55 R. Jockers, M. Ayoub, A. Levoye, C. Borg-Capra, P. Delagrange, J.-L. Guillaume, Paris and Suresnes, France
Modulation of melatonin receptor function by receptor dimerziation and scaffolding proteins
09.55-10.15 Round Table Discussion
10.15-11.15 General Discussion of Posters I
Discussion leader: M. Møller, Copenhagen, Denmark
11.15-11.30

Coffee break
11.30-13.00

Session VII: Rhythm and blues for the clockwork
Chair and Introduction: A. Loudon, Manchester, United Kingdom
11.35-11.55 J. Meijer, Leiden, The Netherlands
The suprachiasmatic nucleus: multioscillator structure with different phase resetting units
11.55-12.15

A. Sumová, Prague, Czech Republic
Circadian clockwork and entrainment during development
12.15-12.35 W. Schwartz, Worcester, USA
Hamsters running on time: is the habenula a part of the clock?
12.35-13.00

Round Table Discussion
13.00-14.00 Lunch
  Oral Presentations (10 min + 5 min discussion)
Chair: R. G. Foster, London, United Kingdom
14.00-14.15 Y. Kwak, G. B. Lundkvist, J. Brask, M. Menaker, K. Kristensson, G. D. Block, Charlottesville, USA; Stockholm, Sweden
Cytokines alter GABA-ergic postsynaptic activity in suprachiasmatic nucleus neurons
14.15-14.30 A. Herwig, F. Revel, P. Pévet, M. Saboureau, S. Steinlechner, Strasbourg, France; Hannover, Germany
Clock genes in torpid hamsters
14.30-14.45 F. G. Revel, M. Saboureau, M. Masson-Pévet, P. Pévet, J. D. Mikkelsen, V. Simonneaux, Strasbourg, France; Ballerup, Denmark
Photoperiodic modulation of sexual activity is under kiss-1 control in Syrian hamster
14.45-15.00 C. Feillet, G. Pendyalla, U. Albrecht, E. Challet, Strasbourg, France; Fribourg, Switzerland
Differential impairment of food synchronisation in Per mutant mice
15.00-16.30

General Discussion of Posters II
Discussion leader: D. C. Klein, Bethesda, USA
16.30-17.00

Coffee break
17.00-18.30 General Discussion of Posters III
Discussion Leader: M. Masson-Pévet, Strasbourg, France
18.45-19.30

Perspective lecture II:
J. Takahashi, Chicago, USA
Genes, cells and circadian clocks: Do we know as much as we think we do?

Chair: M. Menaker, Charlottesville, USA
20.00 Free evening to enjoy Frankfurt

 

Monday, 5th September

09.00-10.50 Session VIII: Melatonin, a hormone for all seasons in Memoriam Eberhard Gwinner, Andechs, Germany
Chair and Introduction: H. Illnerová, Prague, Czech Republic
09.05-09.25 A. Foà, Ferrara, Italy
Seasonal changes in the circadian organization of lizards: role of melatonin and the pineal
09.25-09.45 R. Brandstätter, Birmingham, United Kingdom
Coordination of circadian and circannual rhythmicity in migratory birds - a role for melatonin?
09.45-10.05 G. Lincoln, Edinburgh, United Kingdom
Melatonin entrainment of circannual rhythms
10.05-10.25 B. Malpaux, Tours, France
Melatonin and seasonal reproduction: implication of cerebrospinal fluid melatonin in the integration of photoperiod
10.25-10.50 Round Table Discussion
10.50-11.10 Coffee break
11.10-12.10 Session IX: Biological rhythms in health and disease
Chair and Introduction: D. Skene, Guildford, United Kingdom
11.15-11.35 K. Kräuchi, Basel, Switzerland
Melatonin, thermoregulation, skin blood flow and sleepiness in humans
11.35-11.55 A. Lewy, Portland, USA
Pad 6: the “sweet spot” for correcting circadian misalignment between the endogenous melatonin rhythm and the sleep/wake cycle
11.55-12.15 G. Brainard, Philadelphia, USA
Adapting the human circadian system to ambient light on mars
12.15-12.40 Round Table Discussion
12.40-13.30 Lunch
13.30-14.15 Oral Presentations (10 min + 5 min discussion)
Chair: J. Arendt, Guildford, United Kingdom
13.30-13.45 U. Albrecht, M. C. Magnone, S. Langmesser, T. Tallone, S. Rusconi, Fribourg, Switzerland
The mammalian circadian clock gene Per2 modulates cell death in response to oxidative stress
13.45-14.00 S. Montagnese, B. Middleton, A. Mani, D. J. Skene, M. Y. Morgan, London and Guildford, United Kingdom
Disruption of the retinal-pineal pathway in patients with cirrhosis?
14.00-14.15 K. Wulff, E. Joyce, B. Middleton, D.-J. Dijk, R. G. Foster, London and Guildford, United Kingdom
The relationship between light exposure, melatonin rhythms and abnormal rest-activity timing in schizophrenia patients: a comparison with unemployed controls
14.15-15.30 General Discussion of Posters IV
Discussion leader: P. Pévet, Strasbourg, France
15.30-16.00 Coffee break
16.00-17.05 Young Investigators’ Forum
Chair and Introduction: J. H. Stehle, Frankfurt/Main, Germany
16.05-16.20 U. Abraham, J. D. Prior, D. Granados-Fuentes, D. R. Piwnica-Worms, E. D. Herzog, St. Louis, USA
The olfactory bulb displays independent circadian oscillations of Period1 in vivo and in vitro
16.20-16.35 S. Michel, J. P. Clark, J. M. Ding, C. S. Colwell, Leyden, The Netherlands; Mineapolis, Greenville; Los Angeles, USA
Brain derived neurotrophic factor modulates glutamatergic transmission in the suprachiasmatic nucleus
16.35-16.50 J. A. Ripperger, M. Stratmann, U. Schibler, Geneva, Switzerland
Circadian transcription and methylation of histones at the mouse Dbp gene
16.50-17.05 T. Serchov, A. Jilg, J. H. Stehle, R. Heumann, Bochum and Frankfurt/Main, Germany
Neuronal activation of Ras in the suprachiasmatic nucleus and pineal gland of the mouse
17.05-18.30 General Assembly

Concluding Remarks
18.30-19.15 Perspective lecture III:
T. Roenneberg, Munich , Germany
Entrainment: life between clocks

Chair: C. Green, Charlottesville, USA
19.30 Banquet at the Senckenberg Museum Frankfurt